Commercial authority for growth‑stage SaaS in an AI-shaped market.
Andrew Wyatt works with CEOs, chairs and PE and VC-backed boards on the moves that decide the next stage.
Lotus to IBM $3.5B · Paragon to Phone.com $500M · Apertio to Nokia $240M · Clearswift to Lyceum $50M
Clarity when it counts.
Boards do not need more material. They need a catalyst. The one input that dissolves the noise and leaves the room with a decision the company can act on. Every Ortent engagement is built around that single act of clarification: drop in, dissolve the complexity, leave the call.
// THE ORTENT PRINCIPLEFive ways to work with Andrew.
Pick the shape that matches the decision on the table.
Sprint
One question, one board-ready answer. Fixed scope, fixed timeline.
Read more → One quarter90-day Diagnostic
Full commercial and operating read. Twenty questions against evidence.
Read more → OngoingAdvisory
Standing counsel to CEO or Chair. Monthly cadence, defined scope.
Read more → Executive seatFractional CGO
Part-time commercial leadership through the scale-up years.
Read more → Board seatNon-executive director
Board contribution grounded in operator experience, not observer commentary.
Read more →What people say.
"Andrew is one of the few SaaS leaders I've worked with who genuinely understands how to build commercial relationships at the intersection of life sciences and software. He thinks like a partner, not a vendor, which is exactly what makes the work move."
"Andrew's one of those rare breeds who really understands technology, but also has the listening and strategic skills to read customers and markets. Smart guy."
"Andrew approaches AI-related commercial, legal, and privacy risks with a deep understanding and the strategic insight of a board member. He excels at balancing the potential for revenue growth and competitive advantage with the necessary regulatory compliance and risk management, all while communicating these complexities with ease."
"Andrew is one of the sharpest commercial operators I've worked with, and a charismatic leader people love to work for. He sees the GTM motion and the customer simultaneously, and he builds partner ecosystems that drive pipeline rather than just logo slides."
"Zifo and Sapio have collaborated closely for several years, working together to ensure seamless integration of the Sapio Platform with our Lab Data Automation Solution. By combining our expertise in scientific informatics services with Sapio's lab informatics solutions, we can provide our customers with a world-class approach to lab automation and further the adoption of AI in biotech and pharma."
"The partner program Andrew built at Sapio set a new bar for what life sciences software ecosystems can look like. He made it easy for global services partners like Cognizant to invest, deliver, and grow alongside the platform, which is rarer than it should be."
"Working with Andrew on the Sapio and Elsevier collaboration showed me what AI ecosystem thinking looks like in practice. He moves the conversation past 'how do we integrate?' and into 'how do our two products make each other more valuable?'. That design instinct is what separates a partnership that compounds from a logo on a slide."
Working tools, not decks.
Seven artefacts a CEO or Chair can drop in front of their team and use. Free. No email capture.
- The Growth-Stage TOM Diagnostic
- NHS Readiness Diagnostic NHS
- NHS Board Radar Radar
- Partner Architecture Visualiser Framework
- Five Questions Diagnostic Scorecard
- Reinventors AI revenue
- The AI Value Gap survey Research
The Growth Chair.
Weekly on Substack and inside LinkedIn. Board-facing commentary on growth-stage SaaS, life sciences and the AI value gap.
Partner-Led Growth for PE-backed B2B SaaS.
Most partner programmes are four programmes pretending to be one. That conflation kills more partner revenue than the economics ever do. The guide sets out the four archetypes, the AI co-growth model, and how to measure a partner ecosystem that compounds rather than just adds logos to a slide.
Andrew Wyatt.
Thirty years in B2B SaaS. Four exits: Lotus to IBM ($3.5B), Paragon Software to Phone.com ($500M), Apertio to Nokia ($240M), Clearswift to Lyceum Capital ($50M).
Most recently Chief Growth Officer at Sapio Sciences and Sigmatic Sciences. Before Sapio, Chief Operating Officer at Lumeon. Ortent is the vehicle for advisory, board and fractional executive work with growth-stage life sciences and AI SaaS.
Questions, answered.
What is Ortent Advisory?
Ortent is an operator-led advisory for growth-stage B2B SaaS businesses serving life sciences, digital health and AI markets. Five ways to work: Sprint, 90-day Diagnostic, Advisory, Fractional CGO, and Non-Executive Director. Founded and run by Andrew Wyatt.
Who does Ortent work with?
Typically PE operating partners, new CEOs inside their first 100 days, and chairs preparing a company for exit. The common thread is growth-stage SaaS where commercial clarity, operating maturity and partner-led growth are material to value.
What are the five ways to work with Andrew?
Sprint is a two-week fixed-scope engagement that answers one commercial question in board-ready form. 90-day Diagnostic is a quarter-long read across the full commercial and operating model, delivered as a written diagnostic, target operating model and board pack. Advisory is a monthly retainer with the CEO or Chair, three-month minimum. Fractional CGO is part-time executive commercial leadership, typically two days a week. Non-Executive Director is a board seat grounded in operator experience, committee-ready.
What does an engagement cost?
Sprint and 90-day Diagnostic are fixed fee, agreed before work starts. Advisory is a monthly retainer with a three-month minimum. Fractional CGO is a day rate, typically two days a week. Non-Executive Director appointments are on standard NED terms. Fee detail for each engagement is on the services pages.
How does an engagement start?
Most start with a Sprint or a 90-day Diagnostic. Send a note through the contact page and we book 30 minutes to test whether the fit is there. Every engagement is built around a written artefact the board can act on.
Who is Andrew Wyatt?
Andrew Wyatt is the principal of Ortent Advisory, a commercial operator with 30 years in enterprise software and four company exits behind him. He works with boards and leadership teams of SaaS companies in life sciences, digital health and AI. Based in London.
Clarity when it counts.
For a board, advisory or fractional engagement, or a working call on the next stage, email directly. Thirty minutes is usually enough to test fit.
Book a 30-minute intro call