Life sciences · Digital health · AI-native SaaS

Commercial authority for growth‑stage SaaS in an AI-shaped market.

Andrew Wyatt works with CEOs, chairs and PE and VC-backed boards on the moves that decide the next stage.

Lotus to IBM $3.5B · Paragon to Phone.com $500M · Apertio to Nokia $240M · Clearswift to Lyceum $50M

// THE PRINCIPLE

Clarity when it counts.

Boards do not need more material. They need a catalyst. The one input that dissolves the noise and leaves the room with a decision the company can act on. Every Ortent engagement is built around that single act of clarification: drop in, dissolve the complexity, leave the call.

// THE ORTENT PRINCIPLE
The five ways in

Five ways to work with Andrew.

Pick the shape that matches the decision on the table.

Said in the room

What people say.

Dr Joanne M. Hackett, IQVIA
"Andrew is one of the few SaaS leaders I've worked with who genuinely understands how to build commercial relationships at the intersection of life sciences and software. He thinks like a partner, not a vendor, which is exactly what makes the work move."
Dr Joanne M. Hackett· VP, Global Head of Health System Services, IQVIA
Mike Reid, Frog Capital
"Andrew's one of those rare breeds who really understands technology, but also has the listening and strategic skills to read customers and markets. Smart guy."
Mike Reid· Founder & Senior Partner, Frog Capital
Rachel Webber, General Counsel and AI Governance Specialist
"Andrew approaches AI-related commercial, legal, and privacy risks with a deep understanding and the strategic insight of a board member. He excels at balancing the potential for revenue growth and competitive advantage with the necessary regulatory compliance and risk management, all while communicating these complexities with ease."
Rachel Webber· General Counsel and AI Governance Specialist
Rick Halton, Fractional CMO and SaaS Marketeer
"Andrew is one of the sharpest commercial operators I've worked with, and a charismatic leader people love to work for. He sees the GTM motion and the customer simultaneously, and he builds partner ecosystems that drive pipeline rather than just logo slides."
Rick Halton· Fractional CMO and SaaS Marketeer
Raj Prakash, Co-Founder and CEO of Zifo
"Zifo and Sapio have collaborated closely for several years, working together to ensure seamless integration of the Sapio Platform with our Lab Data Automation Solution. By combining our expertise in scientific informatics services with Sapio's lab informatics solutions, we can provide our customers with a world-class approach to lab automation and further the adoption of AI in biotech and pharma."
Raj Prakash· Co-Founder and CEO, Zifo
Venkat Kannan, CDS and Lab Automation Lead NA, Cognizant
"The partner program Andrew built at Sapio set a new bar for what life sciences software ecosystems can look like. He made it easy for global services partners like Cognizant to invest, deliver, and grow alongside the platform, which is rarer than it should be."
Venkat Kannan· CDS and Lab Automation Lead NA, Cognizant
Sudi Jessurun, Director Market Development, Elsevier
"Working with Andrew on the Sapio and Elsevier collaboration showed me what AI ecosystem thinking looks like in practice. He moves the conversation past 'how do we integrate?' and into 'how do our two products make each other more valuable?'. That design instinct is what separates a partnership that compounds from a logo on a slide."
Sudi Jessurun· Director Market Development, Elsevier
Interactive diagnostics

Working tools, not decks.

Six artefacts a CEO or Chair can drop in front of their team and use. Free. No email capture.

See the tools →
Latest thinking

The Growth Chair.

Weekly on Substack and inside LinkedIn. Board-facing commentary on growth-stage SaaS, life sciences and the AI value gap.

Loading the latest three essays.
Read the archive →
// The thesis

Partner-Led Growth for PE-backed B2B SaaS.

Most partner programmes are four programmes pretending to be one. That conflation kills more partner revenue than the economics ever do. The guide sets out the four archetypes, the AI co-growth model, and how to measure a partner ecosystem that compounds rather than just adds logos to a slide.

Four archetypes AI co-growth Compound revenue Board-facing measurement
Read the pillar →
Andrew Wyatt, Principal, Ortent Advisory Ltd
Who

Andrew Wyatt.

Thirty years in B2B SaaS. Four exits: Lotus to IBM ($3.5B), Paragon Software to Phone.com ($500M), Apertio to Nokia ($240M), Clearswift to Lyceum Capital ($50M).

Most recently Chief Growth Officer at Sapio Sciences and Sigmatic Sciences. Before Sapio, Chief Operating Officer at Lumeon. Ortent is the vehicle for advisory, board and fractional executive work with growth-stage life sciences and AI SaaS.

// GET IN TOUCH

Clarity when it counts.

For a board, advisory or fractional engagement, or a working call on the next stage, email directly. Thirty minutes is usually enough to test fit.

Book a 30-minute intro call